Question 1

Which topical retinoids molecule has the most API manufacturers?

Accepted Answer

Adapalene, with 16 manufacturers holding an active regulatory filing, of which 10 hold an active US DMF or a valid CEP. Counts come from the FDA drug master file list and the EDQM certificate database, as at 9 July 2026.

Question 2

How many API manufacturers cover the topical retinoids class?

Accepted Answer

Across the 3 topical retinoids molecules tracked here (ATC D10AD), 36 active filings are held by manufacturers worldwide. Some companies file for several molecules in the class, so the per-molecule pages name each holder.

Topical retinoids: API manufacturers by molecule

Adapalene API manufacturers

Isotretinoin API manufacturers

Tretinoin API manufacturers

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