Suppliers / F.I.S. Fabbrica Italiana Sintetici

F.I.S. Fabbrica Italiana Sintetici

Italy reconciled across 7 public records · 3 entities Updated 9 July 2026

F.I.S. Fabbrica Italiana Sintetici is an API manufacturer based in Italy. It holds 43 active US drug master files. Its GMP standing is certified by EMA and ANVISA (Brazil). Its most recent recorded inspection, by US FDA, closed on 28 October 2022 as VAI.

43
active US DMFs
0
valid CEPs
7
registered plants 3 with an FDA FEI number
9
filings across 1 regulators
These figures were checked against the regulators' own files on 25 July 2026
Plants
3 of 3 confirmed
Inspections
8 of 8 confirmed
EU GMP
1 of 1 confirmed
Sources: FDA Establishment Registration, read 4 May 2026. FDA drug inspection classifications, read 4 May 2026. EudraGMDP (MIA + third-country GMP certs), read 4 May 2026.

Inspection history

  • 28 October 2022 VAI US FDA
  • 6 May 2022 VAI US FDA
  • 17 September 2021 VAI US FDA
  • 5 July 2019 VAI US FDA
  • 6 July 2018 VAI US FDA
  • 1 June 2018 VAI US FDA
  • 17 February 2017 NAI US FDA
  • 25 February 2016 NAI US FDA
  • 29 May 2015 NAI US FDA
  • 23 April 2015 NAI US FDA
  • 7 February 2013 VAI US FDA
  • 5 April 2012 NAI US FDA

NAI means no action indicated, VAI means voluntary action indicated, and OAI means official action indicated.

Registered plants

Site FDA FEI
VICENZA, Italy Not on file
TERMOLI, Italy Not on file
Italy, Italy 3002806961
Italy, Italy 3008347496
Italy, Italy 3002808541
LONIGO, Italy Not on file

1 further sites are on record.

What they file, and where

Molecule Regulators Docs
Nitrofurantoin US FDA 3
Acetylcysteine SFDA (Saudi Arabia), US FDA 2
Diazepam SFDA (Saudi Arabia), US FDA 2
Dorzolamide SFDA (Saudi Arabia), US FDA 2
Imatinib US FDA 2
Indomethacin US FDA 2
Pentazocine US FDA 2
Ataluren SFDA (Saudi Arabia) 1
Carbamazepine US FDA 1
Chlordiazepoxide US FDA 1
Show all 40 molecules on file
Clobazam US FDA 1
Clomifene US FDA 1
Clonazepam US FDA 1
Clotrimazole US FDA 1
Dexlansoprazole SFDA (Saudi Arabia) 1
Diltiazem US FDA 1
Eletriptan US FDA 1
Enclomiphene US FDA 1
Entacapone SFDA (Saudi Arabia) 1
Estazolam US FDA 1
Flurazepam US FDA 1
Fluvastatin US FDA 1
Fosfomycin US FDA 1
Furosemide US FDA 1
Gabapentin US FDA 1
Lorazepam US FDA 1
Midazolam US FDA 1
Nebivolol US FDA 1
Nifedipine US FDA 1
Nitrofurantoin Macrocrystals SFDA (Saudi Arabia) 1
Olopatadine US FDA 1
Oxazepam US FDA 1
Oxcarbazepine US FDA 1
Phloroglucinol SFDA (Saudi Arabia) 1
Prasterone US FDA 1
Progesterone US FDA 1
Quetiapine US FDA 1
Ranolazine SFDA (Saudi Arabia) 1
Rifaximin US FDA 1
Safinamide US FDA 1

Also appears on these molecule pages

Show 21 more molecule pages

Filings and GMP by regulator

Regulator Filings GMP certificates
MINSA (CR) 9 None
EMA None 1
ANVISA (Brazil) None 1

Questions about F.I.S. Fabbrica Italiana Sintetici

Does F.I.S. Fabbrica Italiana Sintetici hold a US DMF or a CEP?
F.I.S. Fabbrica Italiana Sintetici holds 43 active US drug master files. A drug master file is a submission to the FDA describing how an ingredient is made; a CEP is the EDQM's certificate that the substance meets its European Pharmacopoeia monograph. Both are filings rather than approvals.
Is F.I.S. Fabbrica Italiana Sintetici FDA-registered?
3 sites operated by F.I.S. Fabbrica Italiana Sintetici carry an FDA establishment identifier (FEI), which means they are registered with the FDA as a drug establishment. Registration is not the same as approval or inspection clearance.
How did F.I.S. Fabbrica Italiana Sintetici's last inspection go?
The most recent inspection on record closed on 28 October 2022 as VAI (Voluntary Action Indicated: issues were found but did not warrant regulatory action). 15 inspections are on file.
Where does F.I.S. Fabbrica Italiana Sintetici manufacture?
7 registered sites are on record, in Italy (Vicenza, Termoli and Italy among others). Every site is listed on this page with the register it came from.
What does F.I.S. Fabbrica Italiana Sintetici make?
40 molecules are on record against F.I.S. Fabbrica Italiana Sintetici, including Nitrofurantoin, Acetylcysteine, Diazepam and Dorzolamide. Each links through to that molecule's full manufacturer list.
Which regulators recognise F.I.S. Fabbrica Italiana Sintetici's GMP?
Current GMP certificates are on record from EMA and ANVISA (Brazil). GMP recognition covers the manufacturing site, separately from any filing on the substance itself.

Answered from this company's own record. Where a register holds nothing, the question is not asked rather than answered with a zero. How we count our figures.

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Open risk flags

  • 1 active litigation matter is on record.
  • The most recent inspection outcome was VAI, on 28 October 2022.

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Sources on this page

FDA
Drug master files, establishment registration, inspection classifications
EDQM
Certificates of suitability
EudraGMDP and national regulators
GMP certificates