Compare institutional procurement clearing prices to open-market lane medians on the same molecule-destination. The empirical discount that institutional buyers extract.
Dolutegravir clears the open-market India-out lane to South Africa at $8.00/kg median across 149 shipments. The procurement-flow channel to Denmark in 2024 cleared $314k across 10 shipments, implying $31.4k average per shipment. The institutional vs commercial comparison is structural: tender lanes carry larger pack volumes per shipment and tighter delivery windows; the per-kg comparison requires unit normalisation, but the per-shipment value spread is informative directly. On dolutegravir, the institutional pricing tier sits structurally above the high-volume commercial South African tender.
The AI agent pulls both the procurement-flow trade for the destination (when present) and the open-market lane aggregate for the same destination.
Per-shipment economics on the tender channel; per-kg medians on the open-market channel. The brief surfaces both and flags the implied discount or premium.
Citation-anchored brief: tender value and shipment count, open-market median, the spread direction, and a chip on whether the tender channel is currently above or below the open market.
Tender flows and open-market trade are different data sources with different price dynamics. PharmaDB surfaces both at the molecule-destination key so the comparison is direct.
If the tender clearing price is below the open-market median by more than 60%, the bid math typically does not work without scale; the brief flags accordingly.
Where the tender lane is large enough to require dedicated capacity, the brief surfaces the trade-off so the user can plan capacity allocation against the open-market lanes.
Both procurement flows and trade aggregates refresh weekly. The split reruns on every refresh; the brief carries the exact computation timestamp.
A real chat thread in PharmaDB. Type a question, the AI agent runs the tools, the answer lands as a saveable note.
pharmagraph_query Eight dolutegravir destinations · 2024 open-market median in USD/kg · tender channels surfaced where present in procurement_flows.
The tender split is the channel-mix lens. PharmaDB joins procurement_flows to molecule_country_flow at the molecule-destination key and surfaces the per-shipment institutional value alongside the per-kg open-market median. Refresh cadence is weekly.
Tender awards report total value and shipment count, not always normalised to kg. Per-shipment USD is the cleanest direct comparison. When pack-size is consistent (UNICEF, Global Fund), the per-shipment USD divided by typical pack mass approximates the per-kg price.
Procurement-flow records cover UNICEF, Global Fund, PEPFAR, bilateral aid, and similar multilateral procurement programs. The `procurement_flows` table is sparse (480 rows total in the live build); not every molecule-destination pair has tender data.
Cold-chain, specialty packaging, regulatory pre-qualification (WHO-PQ), and tight delivery windows can push tender pricing above commercial. The 'institutional discount' assumption holds for high-volume commodities; specialty tenders can run premium.
The brief still surfaces the open-market median and explicitly notes 'no institutional flow recorded.' This is itself a signal: a destination with no tender flow has either no institutional procurement, or that procurement happens outside the captured aggregates.
When a tender RFP arrives, the user knows both the open-market clearing price and the historical institutional channel price for the same destination. The bid floor incorporates both anchors; the brief surfaces the gap so the user can position above the tender floor while staying below the open-market median.
Both tables refresh weekly. The split recomputes on every refresh; the catalog row carries the exact timestamp.
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